William Nyberg, PhD | Eyquem Lab

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M_MED-CORE-HMON-ONCO-GEN

My name is William Nyberg and before moving to San Francisco I did my PhD at the Karolinska Institute in Stockholm, Sweden. I started my postdoc in the Eyquem lab in August 2019. As a postdoc my focus is on developing CAR T cells targeting solid tumors as well as establishing efficient knock-in platforms for multiple immune cell types using AAVs. I’m a huge football fan (both the American and the European version) and I love to travel and explore new places.

Publications

Localized in vivo gene editing of murine cancer-associated fibroblasts.

bioRxiv : the preprint server for biology

Kuhn NF, Zaleta-Linares I, Nyberg WA, Eyquem J, Krummel MF

Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells.

bioRxiv : the preprint server for biology

Sytsma BJ, Allain V, Bourke S, Faizee F, Fathi M, Berdeaux R, Ferreira LMR, Brewer J, Li L, Pan FL, Rothrock AG, Nyberg WA, Li Z, Wilson LH, Eyquem J, Pawell RS

Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection.

bioRxiv : the preprint server for biology

Chang CR, Vykunta VS, Goodman DB, Muldoon JJ, Nyberg WA, Liu C, Allain V, Rothrock A, Wang CH, Marson A, Shy BR, Eyquem J

Light induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo.

bioRxiv : the preprint server for biology

Pulgarin DV, Pelo N, Ferrandiz L, Trselic T, Nyberg WA, Bowlin G, Espinosa A

Modular pooled discovery of synthetic knockin sequences to program durable cell therapies.

Cell

Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A

An evolved AAV variant enables efficient genetic engineering of murine T�cells.

Cell

Nyberg WA, Ark J, To A, Clouden S, Reeder G, Muldoon JJ, Chung JY, Xie WH, Allain V, Steinhart Z, Chang C, Talbot A, Kim S, Rosales A, Havlik LP, Pimentel H, Asokan A, Eyquem J

RASA2 ablation in T cells boosts antigen sensitivity and long-term function.

Nature

Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A